Since this time many reports of children believed to have been affected by carbimazole in utero have … Report suspected adverse drug reactions via the Yellow Card scheme Please continue to report any suspected adverse drug reactions via the Yellow Card Scheme. Background: Hyperthyroidism is one of the most common endocrine disorders in pregnant women, and it can severely complicate the course and outcome of pregnancy. I have just received an email alert regarding Carbimazole. 4.5 Interaction with other medicines and other forms of interaction Little is known about interactions. MHRA issues warning about use of carbimazole in pregnancy. Only use UKTIS monographs downloaded directly from TOXBASE.org or UKTIS.org to be sure you are using the most up-to-date version. Traditionally, MMI has been considered to have clearer evidence of teratogenicity than PTU. Provide information about your pregnancy to help women in the future. The antithyroid drugs, Carbimazole, Methimazole, and Propylthiouracil remain the mainstay of Graves' disease management in pregnancy. Package leaflet . Carbimazole (Neomercazole) is converted into methimazole after it is absorbed. Before using Carbimazole, inform your doctor about your current list of medications, over the counter products (e.g. This material may be freely reproduced for education and not for profit purposes within the UK National Health Service, however no linking to this website or reproduction by or for commercial organisations is permitted without the express written permission of this service. The main points about which to raise awareness are: 1. Carbimazole and methimazole use in early pregnancy is thought to slightly increase the chance of certain birth defects occurring in the baby. If you have taken or are taking any medicines it is always a good idea to let your doctor know that you are pregnant so that you can decide together whether this is still the best medicine to treat your condition, and if so, to make sure that you are taking the correct dose. If carbimazole is used in pregnancy, the dose must be regulated by the patient's clinical condition. Foulds N(1), Walpole I, Elmslie F, Mansour S. Author information: (1)SW Thames Regional Genetics Services, St. George's Hospital, London, UK. 4.5 Interaction with other medicines and other forms of interaction Little is known about interactions. Every pregnancy is unique. However, please let us know if you are planning to conceive or as soon as you know you are pregnant. However, none of four small scientific studies have shown that children exposed to carbimazole or methimazole in the womb are more likely to have problems with learning and behaviour than children not exposed to these medicines. Suspected Spontaneous Reports of Birth Defects in the UK Associated with the Use of Carbimazole and Propylthiouracil in Pregnancy. Because this drug crosses the placenta and can induce goiter and cretinism in the developing fetus, excessive doses should not be given during pregnancy. If you have taken carbimazole, methimazole or other antithyroid medicines) after week 10 of pregnancy your baby will require extra monitoring after birth because of the risk of altered thyroid function. Therefore, carbimazole should be used in pregnancy only when propylthiouracil is not suitable. Because this drug crosses the placenta and can induce goiter and cretinism in the developing fetus, excessive doses should not be given during pregnancy. Clinicians are reminded of the importance of consideration of such factors when performing case-specific risk assessments. However, an overactive thyroid in pregnancy has been linked to low birth weight in the baby and this may explain why some studies have found that babies of pregnant women taking carbimazole or methimazole tended to be smaller. During pregnancy, it is recommended that the dose of propylthiouracil and carbimazole is kept to the lowest possible needed to maintain euthyroidism, as these drugs cross the placenta and in high doses may cause fetal goitre and hypothyroidism. if carbimazole is used during pregnancy, close maternal, foetal and neonatal monitoring is recommended. J Thyroid Res 2011; 2011:235130. Carbimazole crosses the placenta but, provided the mother's dose is within the standard range and her thyroid status is monitored; there is no evidence of neonatal thyroid abnormalities. 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